Glucocorticoid receptors in lung. Mechanism of specific glucocorticoid uptake by fetal rabbit lung nuclei.
نویسندگان
چکیده
منابع مشابه
Glucocorticoid receptors in lung. I. Specific binding of glucocorticoids to cytoplasmic components of rabbit fetal lung.
Specific binding of glucocorticoids in fetal lung extracts was studied to investigate the mechanism of glucocorticoid action in the developing lung. The cytosol fraction of rabbit fetal lung contains a macromolecule with high affinity (3.8 X 10Mg M) for dexamethasone and with a limited number of binding sites which are saturated with low hormone concentrations (1 X lo-’ M). A much higher concen...
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Pulmonary glucocorticoid receptor (GR) is essential to timely preparation for the onset of breathing air at birth. We have previously used primary culture of late-gestation fetal rat lung cells to demonstrate differential regulation of GR by glucocorticoid depending on cell type. In this study, we hypothesized that the action of glucocorticoid on GR mRNA expression and protein elaboration in lu...
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The specific interaction of glucocorticoids with fetal and adult rabbit tissues was studied in vitro. Specific cytoplasmic binding sites for [aH]dexamethasone were demonstrated in liver, thymus, kidney, lung, muscle, heart, small intestine, skin, brain, and placenta of the rabbit fetus as well as in liver, thymus, spleen, kidney, small intestine, and lung of the adult rabbit. In the rabbit fetu...
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The synthesis of uteroglobin in rabbit lung was studied after the administration of glucocorticoids to intact adult animals as well as during the late stages of rabbit development. The synthesis of uteroglobin was compared with levels of translatable uteroglobin mRNA in the lung. Uteroglobin synthesis was determined both by incorporation of [25S]methionine into the protein by lung explants incu...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1975
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)41572-x